The genetic evidence suggested that all these genes coded for proteins with roles in DSB repair, but what exactly is the role of each at the molecular level? The actual function of each protein is ...

Furthermore, depletion of PIAS1 and PIAS4 causes a decrease in DSB repair by homologous recombination and non-homologous end joining, indicating a functional role for these E3 SUMO ligases in DNA ...

But Storici's team found that RNA can also help cells repair a severe form of DNA damage called a double-strand break, or DSB. A DSB means both strands of the DNA helix have been severed.