Two apoptotic cell-death pathways exist in mammals — a cell ... The cell-extrinsic pathway is initiated by ligand engagement of death receptors, such as FAS (also known as CD95) on the cell ...

Thus, Fas, TRAIL and TNF receptors can initiate cell death by two alternative pathways, one relying on ... cells are removed via silent apoptotic death instead. In contrast, during physiological ...

Specifically, lower activation of the epidermal growth factor receptor (EGFR) signaling pathway ... apoptotic LEC display transiently increased ERK activity, which blocks clustered cell death.