为探究蝙蝠细胞对 SARS-CoV-2 复制产生的双链 RNA（dsRNA）的反应，研究人员开展相关研究，发现 Dicer 参与限制病毒复制，对理解蝙蝠抗病毒机制及相关疾病治疗有重要意义。 蝙蝠与 SARS-CoV-2 的奇妙 “共处” 之秘：Dicer 的独特作用 在大自然的病毒 “库藏” 中 ...

RNA 干扰（RNAi）和自噬作为细胞内重要的抗病毒防线，一直是科学家们关注的焦点。RNAi 就像细胞内的 “精确制导武器”，能通过 Dicer 蛋白切割病毒双链 RNA（dsRNA）形成小干扰 RNA（vsiRNA），精准打击病毒的同源 RNA，阻断其复制。而自噬则如同细胞的 “清道夫 ...

Viroid replication generates dsRNA intermediates, which are processed by Dicer into 21- to 25-nucleotide siRNAs. These siRNAs are then incorporated into siRNA – ribonuclease complexes (RISC). If the ...

Both SGS3 and a viral suppressor of RNA silencing have now been shown to selectively bind 5′ overhang–containing dsRNA, implicating this RNA as a new intermediate in the RNA silencing pathway.

Courtesy of Roger J. Pomerantz and the Center for Human Virology and Biodefense ©2003 John Wiley & Sons, Ltd. Dicer cleaves exogenous or endogenous double-stranded RNA (dsRNA) into 21–25-nucleotide ...

Slicer Dicer is a powerful, self-service data exploration tool integrated into Drexel’s Epic system, designed to support researchers in their data-driven projects. To begin using Slicer Dicer, simply ...