Diclofenac sodium 1.5% ... Hypertension; monitor BP closely. Hepatic or renal impairment. Discontinue if signs/symptoms of liver disease develop, or if abnormal LFTs persist or worsen.

was selected in order to mimic the intramuscular injection in terms of plasma concentration. The initial dose of the comparator, diclofenac potassium, was determined accordingly and identified as ...