Work in our group has used literature and database searches to collect a set of proteins structurally characterized to have regions of disorder, some of which were indicated by NMR to be wholly ...

When these amyloid protein structures clump together in the brain, these deposits—so-called plaques—increase the risk of developing Alzheimer's disease and other neurodegenerative disorders.

The platform has already been tested through successful proof-of-concept studies on novel disordered proteins with major pharmaceutical companies. By utilizing Oppenheimer, for instance ...

Researchers of Mainz University and EMBL Hamburg present a new approach to determine the form of disordered proteins by using two different methods simultaneously in a single sample. Proteins are ...

1.Endo R., Chen Y.K., Burke J., Takashima N., Suryawanshi N., Hui K.K.,Miyazaki T., Tanaka M.: "Dysregulation of ribosome-associated quality control elicits cognitive ...

Regions in protein sequences that are intrinsically disordered are known to play ... dynamics simulations use computers to ...

Scientists uncover key proteins driving brain aging ... and Parkinson’s disease (PD) (a movement disorder characterized by tremors, stiffness, and slow movement). Despite their prevalence ...