Recent studies demonstrate that prolongation of the QT interval is not the sole determinant of the potential of a drug to cause TdP; agents that do not increase transmural dispersion of ...

Patients may be at a greater risk for developing fatal arrhythmias when taking many of these drugs. In general, antipsychotics cause Q-T interval prolongation at a higher rate than do antidepressants.

and excretes the drug. Importantly, APR-1051 may not cause QT prolongation—a condition that can lead to irregular heart rhythms—at doses that significantly inhibit WEE1. APR-1051 was ...