Impact of the stem cell niche on aging: we study the communication between stem cells and their niche (e.g. neighbor cells, ECM) in multiple tissues including the intestine, mammary, skeletal muscle, ...

Organization of different cell types and the extracellular matrix (ECM ... interplay can lead to complications in tissue regeneration or to hypertrophy and cancer. We investigate how the composition ...

Ovarian cancer (OC), the most lethal gynecological malignancy, is the fifth leading cause of cancer-related death in women.

Researchers have identified the molecular and cellular mechanisms that transform healthy stem cells into oral cancer at the earliest stages of the disease. Nearly 60,000 people are diagnosed with ...

Now, researchers at University of California San Diego have discovered how healthy stem cells are transformed into cancer stem cells in the earliest stages of the disease. By activating a ...

An international research team led by a Boston College professor has uncovered a drug and diet pairing that could fight a deadly brain cancer The international team combined a calorie-restricted diet ...

Feb. 4, 2025 — Research has shown that a potential new targeted therapy for childhood brain cancer is effective in infiltrating and killing tumor cells in ... How Healthy Stem Cells Turn Into Or ...

In addition, he studies the spindle assembly checkpoint which ensures proper chromosome segregation and is often deregulated in cancer. Joan Massagué, PhD Joan Massagué studies the control of stem ...

Organoids contain multiple organ-specific cell types ... other and ECM proteins, thereby mimicking the functionality and structure of organs in vivo. This allows researchers to model organ-specific ...

Our laboratory aims at exploiting recent advances in stem cell biology to develop radically new therapies for degenerative disease and cancer. The main focus in the lab is on the biology and ...