This study revealed an association between elevated hepatic histamine levels and erythropoietic protoporphyria progression.

Erythropoietic protoporphyria is a genetic disease in which ferrochelatase ... cDNA to bone marrow suppresses the skin photosensitivity of EPP mice. Liver function was monitored by measuring ...

could potentially treat erythropoietic protoporphyria (EPP), a condition that creates extreme skin light sensitivity and can produce toxic levels of protoporphyrin in the liver, bone marrow ...

could potentially treat erythropoietic protoporphyria (EPP), a condition that creates extreme skin light sensitivity and can produce toxic levels of protoporphyrin in the liver, bone marrow ...

While skin photosensitivity is the primary symptom ... and its potential for developing targeted therapies for EPP-associated liver disease. In the present study, the methods involved high ...

EPP is a rare condition, affecting an estimated 4,000 ... effectiveness of chlorcyclizine in EPP patients for both liver and skin involvement. A phase 2 clinical trial is already underway, testing ...

The only way people with EPP can avoid phototoxicity is to avoid light, as there are no other approved treatments for the disease ... of two forms of the natural skin pigment melanin.