Iron overload, characterized by elevated serum ferritin levels, has long been associated with various systemic complications, yet its impact on skeletal health has not been as well understood. A ...

This can result in elevated serum ferritin, iron deposition in various organs and ultimately end-organ damage, although there is incomplete biochemical and clinical penetrance and variable ...

HH has incomplete penetrance; although a majority of the C282Y homozygotes develop elevated serum ferritin (SF) and transferrin saturation (TS), less than half develop any symptoms and about 28% ...

A phase 3 trial highlights betibeglogene autotemcel as a potentially curative gene therapy for severe transfusion-dependent β ...