引言在哺乳动物的胚胎发育过程中，内胚层（endoderm）是形成重要器官的基础，特别是呼吸系统和消化系统。然而，内胚层如何从一个简单的细胞层分化为这些复杂器官的过程，直到今天依然充满了未知。随着研究手段的进步，研究人员逐渐揭开了这一复杂过程的面纱。1月16日Cell的研究报道“Spatiotemporal and genetic cell ...

After exposure to trans-retinoic acid, these cells can develop into two distinct forms of extra-embryonic endoderm. To date, differential library screening has been the best tool available to ...

The authors found that in mice lacking p63, the specification of primitive endoderm into thymic cells seemed to occur normally, but by birth, the epithelium was dramatically smaller in size 10.

Our research focus and goals - how cells form tissues. We are interested in how cells become specialized, and how they collaborate at the population level to collectively build organs. Our focus is on ...

Further cell divisions lead to the formation of the primitive endoderm, which forms a blastocyst. This structure implants around one week after fertilization. As development continues, the epiblast ...

To treat his impaired islet cell function, the research team generated functional islet-like clusters, called “E-islets,” from the patient’s own endoderm stem cells derived from blood cells.

Other cytokines, such as Activin A, are crucial for differentiating induced pluripotent stem cells and embryonic stem cells into endoderm cells—the innermost layer of cells in developing embryos. Yet ...

Pluripotent stem cells have the potential to differentiate into any of the three primary tissue types—endoderm (such as the ...