She named the protein clathrin for its ability to form lattice-like structures (Pearse 1976). By sequencing clathrin protein fragments (peptides), Pearse discovered that the protein was highly ...

Clathrin-mediated endocytosis is a major endocytic route used by transferrin, growth-factor receptors and pathogenic viruses during infectious entry. Although clathrin-dependent uptake is the best ...

One major challenge in making these improved lipids was the difficulty of creating branched ionizable lipids—key components of LNPs that change their charge to help them escape the endosome.