Enhancers bind transcription factors, which then help initiate transcription of the RNA at the promoter. Enhancers accomplish this independently of their distance and location with respect to the ...

"A complementary study from Evgeny Kvon's lab at UC Irvine, examined the relationship between enhancer-promoter activity in ...

They employed Cap Analysis of Gene Expression (CAGE) and Native Elongating Transcript (NET)-CAGE to identify and quantify the activity of promoters and enhancers at a genome-wide level.

They employed Cap Analysis of Gene Expression (CAGE) and Native Elongating Transcript (NET)-CAGE to identify and quantify the activity of promoters and enhancers at a genome-wide level.

This points to a shared genetic mechanism for the two processes during which enhancers, once activated, become ‘loopy’ and reach out to their target gene promoters. The team has validated this model ...

The 3D looping of DNA brings enhancers and the promoters of their target genes ... using a statistical method that can infer causal relationships between phenomena and by forcibly inactivating ...