近日，中南大学湘雅医院骨科/老年骨关节疾病防治教育部重点实验室/国家老年疾病临床医学研究中心雷光华/曾超/魏捷教授团队与中国科学院上海药物研究所谢岑研究员团队合作，在《Science》以“Research ...

近日，中南大学湘雅医院与中国科学院上海药物研究所团队合作在《Science》 以“Research Article”形式在线发表题为“靶向肠道法尼醇X受体调控胰高血糖素样肽-1介导的肠-关节轴治疗骨关节炎（Osteoarthritis ...

By analyzing two independent Chinese cohorts, researchers from the CAS' Shanghai Institute of Materia Medica and Xiangya ...

Bile acids also modulate several nuclear hormone receptors including farnesoid X receptor (FXR; also known as NR1H4). Through activation of these diverse signalling pathways, bile acids have been ...

The farnesoid X receptor (FXR) is a bile acid nuclear receptor that plays a crucial role in regulating bile acid and sterol metabolism. Bile acids are natural ligands of FXR, which bind to the ...

The farnesoid X receptor (FXR) is a bile acid nuclear receptor that plays a crucial role in regulating bile acid and sterol metabolism. Bile acids are natural ligands of FXR, which bind to the ...

Animal experiments demonstrated that GUDCA alleviates osteoarthritis by inhibiting the intestinal FXR receptor and increasing glucagon-like peptide-1 (GLP-1) production. Published in Science with ...

The sequence homology across the nuclear receptor superfamily indicates that these receptors evolved through divergent evolution 5, but gives no information about the role of ligands in the ...

They do all this by binding to a receptor called FXR, which acts like a traffic light, controlling cholesterol metabolism and ...

ACC, Acetyl-CoA Carboxylase; PPAR, peroxisome proliferator–activated receptor; MPC, mitochondrial pyruvate carrier; THR, thyroid hormone receptor; ASK-1, apoptosis signaling kinase-1; GLP-1R ...