The now free IgGs bind to the neonatal Fc receptor (FcRn), which protects them from the cell’s “garbage disposal system” and transports them to the cell surface. There, exposure to the neutral pH of ...

FcRn, an integral endosome membrane protein, binds to IgGs and recycles them either into the circulation or the extracellular space (both pH neutral), where they are released. The other proteins ...

In the vast landscape of antibody drug development, the interaction between IgG and neonatal Fc receptor ( FcRn ) stands as an undeniable cornerstone. This interaction profoundly shapes the ...

This year at AAN, we are sharing more evidence demonstrating the long-term benefits of VYVGART for patients living with gMG and CIDP,” said Luc Truyen, M.D., Ph.D., Chief Medical Officer at argenx.

SPRING HOUSE, PA — Johnson & Johnson has unveiled groundbreaking findings on nipocalimab, an investigational FcRn blocker ... The drug’s binding is pH-independent, a trait that makes it ...

Largest safety data set on FcRn blocking demonstrates consistent ... we are sharing more evidence demonstrating the long-term benefits of VYVGART for patients living with gMG and CIDP,” said Luc ...

Immunovant’s IMVT-1402 is highlighted as the most convenient FcRn inhibitor in late-stage development, featuring an easy-to-use subcutaneous auto-injector. The drug’s potential for deeper IgG ...

Largest safety data set on FcRn blocking demonstrates consistent ... patients living with gMG and CIDP,” said Luc Truyen, M.D., Ph.D., Chief Medical Officer at argenx. “Our breadth of data ...