This leads to leads to anemia, as well as congestion ... fraction of RBCs still contain a mixture of fetal and adult hemoglobin. Because the sickle-cell mutation is present only on the β-globin ...

Aruvant is developing ARU-1801, a one-time, potentially curative gene therapy for sickle ... functional fetal hemoglobin in β-thalassemia patients and restore normal red blood cell function.

Sickle cell anemia is one of the sickle cell disease ... Hydroxyurea increases the generation of fetal hemoglobin. This can prevent the blood cells from becoming sickle cells.

Hydroxyurea Significantly Reduces Infections in Children With Sickle Cell Anemia Jan. 29, 2024 — Researchers have revealed that hydroxyurea significantly reduces infections in children with ...

New data from a Phase 1b clinical trial testing Fulcrum's pociredir for sickle cell disease are expected by the middle and ...

Stem cell transplant in young adults and adolescents with severe sickle cell disease may be a feasible option, according to a ...

This causes the cells to stiffen into a sickle shape, clogging blood vessels and causing pain episodes. Casgevy works by enabling people to produce a fetal form of hemoglobin that doesn't cause ...

Though he doesn't remember it, Branden Baptiste had his first sickle ... treat his cells with a virus carrying instructions for his red blood cells to make a fetal form of hemoglobin.

Targeted Gene Modification in Hematopoietic Stem Cells Using Zing Finger Nucleases (ZFNs): A Potential Treatment for Thalassemia and Sickle Cell Anemia. Humans produce different types of ...

IMMvention Therapeutix, Inc., a Durham early-stage biotechnology company focused on discovering and developing human ...

IMMvention Therapeutix, Inc ., an early-stage biotechnology company focused on discovering and developing human therapeutics, today announced a strategic collaboration and license agreement with Novo ...