研究人员们巧妙地利用荧光共振能量转移（FRET, Fluorescence resonance energy transfer）原理，将PTEN蛋白改造为构象敏感的"分子探针"。通过在其N端和C端分别标记绿色荧光蛋白（mEGFP）与淬灭蛋白（sREACh），团队成功捕捉到PTEN从闭合态到开放态的构象转变，这种仅0.3纳秒的荧光寿命变化（从2.20 ns到2.53 ...

An amino acid is administered before the procedure. King Faisal Specialist Hospital & Research Centre (KFSHRC) in Jeddah has ...

Researchers reveal that the loss of mucin-type O-glycosylation in the brain endothelial glycocalyx weakens the blood-brain ...

Scientists have come up with a way to make whole brain s transparent, so they can be labeled with molecular markers and imaged using a light microscope. The technique, called CLARITY, enabled its ...

In mice, the neurons that dictate the feeling of being full are also the ones that cause sugar cravings, potentially explaining why people are still able to eat sweets after a filling meal ...

The buildup of knot-like RNA structures in brain cells may be the key to understanding how uncontrolled protein aggregation drives Alzheimer’s disease.