二氢嘧啶脱氢酶（DPD）在 5-氟尿嘧啶（5-FU）及其前药卡培他滨的代谢中发挥着关键作用。DPD 是氟尿嘧啶代谢的限速酶，负责将其转化为无活性的代谢物。研究表明，DPD 的缺陷会导致 5-FU 及其衍生药物的代谢能力下降，从而增加患者发生严重毒性反应的风险。根据文献报道，DPD 缺陷在普通人群中的发生率为 3%-5%，而完全缺乏 ...

The following is a summary of “5-fluorouracil 5% cream for squamous cell carcinoma in situ: Factors impacting treatment ...

更糟糕的是，癌症细胞所处的微环境也在 “捣乱”。糖尿病（Diabetes Mellitus，DM）作为 CRC 患者常见的合并症，其引发的高血糖问题对 CRC 的发展影响巨大。高血糖会促进癌细胞的转移和化疗耐药，就像给癌细胞披上了一层 “防护甲”，让它们更加难以被消灭，进而影响患者的预后。 同时，CRC 并非是一种简单的疾病，它存在多种基因改变，对标准治疗的反应各不相同。因此，根据分子特征对 ...

present an important study that applied a high-resolution transposon-based barcoding system to show the clonal contribution of hematopoietic stem and ...

Concomitant 5-fluorouracil (5-FU) was used with EBRT in 90% of patients. Forty-five percent of patients received additional neoadjuvant or adjuvant chemotherapy before or after completing EBRT ...

A new research paper was published in Oncotarget, Volume 16, on February 18, 2025, titled “Leukopenia, weight loss and oral ...

Actinic keratoses are common in older individuals and topical immunotherapy is an important treatment when multiple lesions are present. To assess the efficacy of 5-fluorouracil in treating ...

A new research paper was published in Oncotarget , Volume 16, on February 18, 2025, titled "Leukopenia, weight loss and oral ...

The FDA has updated the product labeling for Xeloda and 5-FU to highlight the risks associated with dihydropyrimidine dehydrogenase deficiency. The U.S. Food and Drug Administration (FDA) has updated ...

More instructions can be found in Section 4. How do I use DBL Fluorouracil Injection BP? in the full CMI. 5. What should I know while being treated with DBL Fluorouracil Injection BP? There are ...