Mice lacking GDNF, or its receptors GFRα1 or RET, die soon after birth sharing the phenotype of kidney agenesis and an absence of many parasympathetic and enteric neurons [1-3]. These animals also ...

Central to the induction of the metanephros (permanent kidney) is the glial-derived neurotrophic factor (GDNF)–RET signalling pathway. Complex molecular networks tightly control GDNF expression ...

纽约 - 市值601万美元的临床阶段生物制药公司Hoth Therapeutics, Inc. (NASDAQ: HOTH) ...

Glial cell line-derived neurotrophic factor (GDNF) plays a vital role in promoting motor neuron survival and axon outgrowth. It is being evaluated in clinical trials as a potential therapeutic for ...

GDNF has been hailed as a potential breakthrough for Parkinson’s ever since it was discovered in 1993. In the lab, it was shown to bring dying brain cells back to life and it has proved to be ...

Using a combination of rational drug design methods and a set of biological assays, we identified three scaffolds of chemical compounds specifically targeting the receptors of glial cell line-derived ...

Hoth Therapeutics (HOTH) announced preclinical findings that highlight the potential of Glial Cell Line-Derived Neurotrophic Factor, or GDNF, ...

Protection Against High-Fat Diet-Induced Obesity – GDNF-tg mice exhibited significantly lower body weight and reduced fat deposition despite consuming a high-fat diet. Enhanced Fat Burning and E ...

(NASDAQ: HOTH), a clinical-stage biopharmaceutical company, today announced preclinical findings that highlight the potential of Glial Cell Line-Derived Neurotrophic Factor (GDNF) as a ...

Glial cell line-derived neurotrophic factor (GDNF) is important for the development and maintenance of dopamine neurons. In rodent and primate models of Parkinson disease GDNF can have restorative ...