小胶质细胞是大脑的常驻免疫细胞，通过动态延伸分支持续监测脑环境，并与神经元相互作用以维持稳态。研究表明，小胶质细胞通过Gi蛋白偶联受体（Gi-GPCRs，如P2Y12）调控神经元活动，物理接触可抑制过度活跃的神经元或增强低活性神经元的功能。敲除小胶质细胞的P2Y12受体或通过百日咳毒素（PTX）抑制Gi信号会减少其动态监测 ...

Read the paper: A cryptic pocket in CB1 drives peripheral and functional selectivity Many important drug targets are G-protein-coupled receptors (GPCRs), including those activated by blockbuster ...

A recent study published in Engineering delves into the complex mechanisms of drug addiction, highlighting the crucial role ...

A recent study published in Engineering delves into the complex mechanisms of drug addiction, highlighting the crucial role of astrocytic G ...

Proteins are life's engines, powering processes like muscle movement, vision, and chemical reactions. Their environments-water, lipid membranes, or other condensed phases-are critical to their ...

Salipro Biotech AB, a Swedish biotech company specialising in the stabilisation of challenging drug targets, today announced a research and license agreement with ...