This variability may reflect the heterogeneous nature of autoantibodies targeting GPIb/V/IX, GPIIb/IIIa and other platelet-related ... well defined signaling pathways, and it is conceivable ...

The platelet uses GPIbα to bind von Willebrand factor (VWF) to resist the dislodging force from the bloodstream. The force unfolds the domain of GPIbα that binds VWF, which prolongs ...

Megakaryocytes (MKs) are traditionally recognized for their primary function of platelet production. However, new evidence in recent years suggests they may also possess immunomodulatory functions.