多形性胶质母细胞瘤（GBM）治疗面临诸多难题，如肿瘤异质性、耐药性和免疫抑制。为解决这些问题，研究人员开展了关于 GBM 潜在免疫抑制靶点的研究。结果发现 HMGB3 在 GBM 中高表达，影响肿瘤异质性和免疫抑制，是潜在治疗靶点，为 GBM 治疗带来新方向。 多形性胶质母细胞瘤（Glioblastoma multiforme，GBM）作为中枢神经系统中极为常见且恶性程度极高的肿瘤，一直是医学领域 ...

在 GBM 中的作用。研究人员对来自癌症基因组图谱（TCGA）队列中 GBM 患者的单核苷酸多态性（SNP）和拷贝数变异数据进行体细胞突变分析；运用公开的单细胞 RNA 测序数据，剖析凝血在 GBM 的 TME 中的作用及其潜在生物学机制。 研究人员对中国胶质瘤基因组图谱 ...

Recently, 1,000 gliomas from The Cancer Genome Atlas (TCGA) and Glioma Longitudinal Analysis (GLASS) were analyzed to identify mutational signatures present in these tumors. Most of the mutational ...

(B) Analysis of HMGN2 expression in different grades of glioma via the TCGA, CGGA-693, and CGGA-325 databases. (C) Analysis of the prognostic significance of HMGN2 in glioma via the TCGA ...

This study performed a comprehensive analysis of cuproptosis-related genes (CRGs) in IDH1-mutant glioma samples from the TCGA database. Two novel IDH1-mutant glioma subtypes were identified based ...

Further validation included analyzing glioma datasets from The Cancer Genome Atlas (TCGA) to confirm the prevalence of identified splicing-related neoantigens across a broader patient population.

Opens in a new tab or window This first of four exclusive episodes provides an overview, discussing classification, long-term impact, and why pediatric low-grade glioma is increasingly considered ...

The glioma tumors from 17 individuals (with an average fire-fighting history of 22 years) were compared with those from 18 individuals in non-firefighting occupations.