The glucocorticoid receptor (GR) is the primary mediator of the effects of these hormones, influencing gene expression and cellular functions. While GCs are effective in treating inflammatory and ...

Genetic defects that cause abnormalities in this receptor or in a protein required for its expression at the cell surface result in a potentially fatal disease (familial glucocorticoid deficiency).

How do activation of glucocorticoid receptor-deficient T-cells and dysregulation of COX-2 activity cause mortality? Histological analyses of TGRKO and control mice treated with antibody to CD3ε ...

ABBV-154, an antibody-drug conjugate comprising adalimumab conjugated to a proprietary glucocorticoid receptor modulator, shows potential for extending flare-free periods in patients with ...