What are the mechanisms of glucocorticoid negative feedback regulation of the HPA axis? The glucocorticoid stress hormones, cortisol and corticosterone, have potent widespread effects throughout the ...

Cortisol metabolism and regeneration from inactive glucocorticoids can also be disrupted ... Finally, overactivity of the HPA axis may be related to the high prevalence of psychopathological ...

Obesity is often associated with PCOS, and its presence may be responsible for alterations of the hypothalamic–pituitary–adrenal axis. There are sufficient arguments to suggest that insulin ...

The hypothesis that S1R deficiency causes down-regulation of the glucocorticoid receptor (GR) and attenuates GR-mediated feedback inhibition of HPA axis, as well as stress response of HPA axis ...