CRF01_AE 毒株的 Env 在 375 位有组氨酸（H375），影响对小分子抑制剂的抗性。研究发现 gp41 HR2 区 629 位残基可调节 Env 稳定性及对两类小分子 gp120 抑制剂的敏感性，为理解 HIV-1 Env 耐药机制提供新视角。 引言 HIV-1 包膜糖蛋白（Env）由三个 gp120 外膜亚基和三个 gp41 跨 ...

Recently, these researchers have determined the three-dimensional structure of the HIV-1 Envelope trimeric ectodomain (“Env”), comprised of three gp120 and three gp41 subunits, in its ...

The rest of this HIV-1 envelope protein, which is docked on a gray membrane, are the structures of gp120 and gp41, shown in green, and the transmembrane segment, shown in blue. Disclaimer ...