Knowing that this relationship exists, researchers have built a hypothesis that histone H3 lysine-4 methylation is required for gene activation. However, it has been surprisingly difficult for ...

Chromatin topology can impact gene regulation. Here ... the key chaperone for histone H3-H4 supply. Here the authors present the cryo-EM structure of the CODANIN-1_ASF1A complex, showing that ...

specifically H3. These proteins directly modulate gene expression programs in the brain that contribute to complex biological ...