1972—James Black discovers the H2 receptor and characterizes its antagonist, burimamide. 1999—Researchers at a subsidiary of Johnson & Johnson clone the H3 receptor. 2000—Seven groups in the ...

and French researchers characterized a third histamine receptor—H3—in 1983. The discoveries of the H2 and H3 histamine receptors, though notable, did little to help allergy researchers.

pK D values for 12 antagonists as determined from measurements of CRE-SPAP production from CHO-H3-cells made in the presence of the 12 different agonists. Values represent mean±s.e.mean of n ...

pIC 50 values for 3 H-cAMP accumulation and CRE-SPAP production for the ligands found to be agonists at the histamine H3 receptor in CHO-H3-SPAP cells. Values represent mean±s.e.mean of n ...