HBV 感染始于病毒通过钠离子-牛磺胆酸共转运多肽（NTCP）受体侵入肝细胞。随后，病毒衣壳被转运至核孔复合体，在核孔处解组装并释放 3.2 kb 的 ...

编者按：人类免疫缺陷病毒（HIV）与乙型肝炎病毒（HBV）共感染是一种全球性公共卫生问题，全球约有10%的HIV感染者同时感染HBV，特别是在高风险地区，如非洲和亚洲，这一比例可能更高。在2025年反转录病毒和机会性感染大会（CROI ...

A recent article in the journal Nature Communications describes the structural basis of mimicked HBV/HDV viral peptide drug interaction with its receptor NTCP. HBV, an enveloped DNA virus ...

Dec. 3, 2024 — Hepatitis B virus (HBV) has a narrow host range, mainly infecting hominoids. A new study reveals the structural differences in the liver cell receptor (NTCP) between humans and ...

Right now, nonhuman primate models are only attainable following temporary changes, like adding the HBV entry receptor, a human protein called NTCP, to liver cells with the help of viral vectors.

Previous research has revealed that this difference in infectivity is related to differences in the liver cell-membrane receptor sodium taurocholate co-translating polypeptide (NTCP), which is known ...

No writing assistance was utilized in the production of this manuscript. AT-61; AT-130 Inhibit HBV virion production by inappropriate assembly of capsids (no clinical data available yet ...

This approved therapy is a peptide inhibitor of NTCP requiring daily injections ... chronic impacts of herpesvirus, hepatitis B virus (HBV) and hepatitis delta virus (HDV) infections.