The diversity of HCV makes immunotherapy or vaccine design very difficult. Law et al. have identified broadly neutralizing antibodies from a human with hepatitis C and demonstrated their HCV ...

Also, most of the bNAbs from these chronically infected donors targeted a specific region of the hepatitis C virus, namely the front layer of the so-called E2 protein. The immune system in ...

Only mice inoculated with the plasmid expressing core, E1, and E2 under the EF-1promoter generated HCV-specific effector responses against all three proteins after a single immunization.

Indeed, HCV has been identified as one of the globally ... to mimic specific regions of the viral glycoproteins E1 and E2, known as neutralization epitopes. These were transferred onto synthetic ...

[17] Eight donor mice were immunized with a HCV vaccine containing pVAX-HCV Core, E1 and E2 DNA (100 μg); Core, E1 and E2 protein (25 μg) in PBS solution and montanide (50 μl) ISA-51 (Seppic Inc., ...