A machine learning (ML) model incorporating both clinical and genomic factors outperformed models based solely on either ...

产品活性： Trastuzumab deruxtecan (T-DXd; DS-8201a) 是一种抗人表皮生长因子受体 2 (HER2) 抗体-活性分子偶联物 (ADC)。Trastuzumab deruxtecan 由人源化抗 HER2 ...

1 Human epidermal growth factor receptor 2 (HER2/ErbB2) overexpression, the most studied member of the type I receptor tyrosine kinase family, is present in up to 25% of women with breast cancer ...

A machine learning (ML) model incorporating both clinical and genomic factors outperformed models based solely on either clinical or ...

A machine learning (ML) model incorporating both clinical and genomic factors outperformed models based solely on either clinical or genomic data in predicting which patients with hormone receptor (HR ...

Trastuzumab resistance is partly explained by the coexpression of p95HER2, a truncated receptor fragment of HER2 that retains kinase activity but lacks the extracellular binding domain.

Trastuzumab, a humanized monoclonal antibody directed against the extracellular domain of the HER2 receptor, and lapatinib, a dual reversible EGFR/HER2 TKI, are indicated for the treatment of HER2 ...

GCC-4001 is a cell therapy commercialized by Artiva Biotherapeutics, with a leading Phase II program in B-Cell Non-Hodgkin Lymphoma.