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生物通
21 天
《Cell》HIF 调控内源性逆转录病毒对肾癌免疫治疗的重大意义
研究结果如下: HIF 对 ERVs 的调控:研究人员发现,HIF2 转录因子可上调肾癌中许多相对完整的 ERVs,如 ERV3.2 和 ERV4700 等。通过对 786 - O VHL-/-ccRCC 细胞等多种细胞系进行定量实时 PCR(real - time qPCR)等实验,证实了这些 ERVs 的表达受 HIF2 调控,且这种调控受 DNA ...
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