本研究揭示了BRD4降解剂在HIV潜伏逆转中的作用机制，为HIV治愈提供了新思路（HIV Latency Reversal） 本研究聚焦于HIV治愈策略中的关键环节——潜伏逆转，旨在通过靶向BRD4来激活潜伏的HIV病毒，以便进一步清除。研究发现，尽管BRD4降解剂能够高效降解BRD4蛋白，但 ...

The P-TEFb–containing complexes include 7SK snRNP assembled with PIC on the HIV-1 promoter (1), 7SK snRNP that may not be part of PIC (2), the Brd4:P-TEFb complex (3) and the HIV-1 Tat ...

Microarray data - from Haaland, R.E., Herrmann, C.H., and Rice, A.P. (2005). siRNA depletion of 7SK snRNA induces apoptosis but does not affect expression of the HIV-1 LTR or P-TEFb-dependent cellular ...