HIV-1 Vif induces a unique and prolonged pseudo-metaphase arrest by disrupting phosphatase feedback regulation at the kinetochore.

The culprit is an HIV-1 accessory protein known as viral protein R (Vpr). The findings reported by the researchers answer some of the questions as to why patients receiving successful treatment for ...

which forms the central conical core of HIV that encapsulates the viral accessory and regulatory proteins (Vif, Vpr, Vpu, Nef, Tat and Rev), the Pol proteins (protease (Pro), reverse transcriptase ...

J. Immunol., 196: 1832-1841 (2016). 5.Hagiwara K, Ishii H, Murakami T, Takeshima SN, Chutiwitoonchai N, Kodama EN, Kawaji K, Kondoh Y, Honda K, Osada H, Tsunetsugu-Yokota Y, Suzuki M & Aida Y: ...