本研究揭示了HIV-1逆转录酶（RT）稳定性及二聚化对蛋白酶（PR）激活和Gag-Pol二聚化的影响，为HIV/AIDS治疗提供了新靶点。 本文 ...

Figure 1: Structural organization of Gag-Pol polyprotein in HIV-1. We speculated that the low catalytic activity of the native p6 pol-protease precursor that is observed preceding its maturation ...

HIV-1 Tat has been the vanguard of Pol II transcription elongation control for more than two decades 3.Nevertheless, its mechanism of action has ceased to be recognized as a viral peculiarity only ...

Gag and Gag-Pol, which are necessary for assembling infectious particles and replication of HIV-1. The researchers demonstrated that this extended RNA fold not only promotes ribosome collisions ...

Gilead Sciences announced a significant milestone: the U.S. FDA accepted their New Drug Applications (NDAs) for lenacapavir ...

The Phase III HIV-1 vaccine trial, also known as RV144, began in Thailand in October 2003 and concluded in the summer of 2009; this test-of-concept trial is the largest HIV vaccine study ever ...