本研究揭示了HIV-1逆转录酶（RT）稳定性及二聚化对蛋白酶（PR）激活和Gag-Pol二聚化的影响，为HIV/AIDS治疗提供了新靶点。 本文 ...

本文通过AI辅助设计HIV包膜蛋白（Env）表位移植模型，系统研究了抗体Fc效应功能（ADCC/ADCP）的分子决定因素。研究发现结合 ...

Sequence variations in human immunodeficiency virus (HIV)-1 reverse transcriptase (RT) and protease, the molecular targets of anti-retroviral drug therapy, are prime examples of genes in which ...

Here we show that fd virions displaying peptide RT2 (ILKEPVHGV), corresponding to residues 309–317 of the reverse transcriptase (RTase) of HIV-1, are able to prime a CTL response specific for ...

NNRTIs bind to a hydrophobic pocket near the catalytic site of HIV-1 RT and inactivate enzymatic activity. NNRTI-resistance mutations & their mechanism of drug resistance The most prevalent NNRTI ...

Importantly, it also revealed for the first time how the Alzheimer 's-linked gene, APP, is recombined by using the same type of enzyme found in HIV. The enzyme, called reverse transcriptase (RT ...

More than 46,000 of them had been prescribed a form of HIV-suppressing medications known as reverse transcriptase (RT) inhibitors. Among this subgroup, Alzheimer's diagnoses occurred in about 2.5 ...