RANKL/osteoprotegerin/RANK signaling regulates bone resorption and is essential for osteoclastogenesis, osteoclast activity and survival. Canonical Wnt signaling regulates bone formation and is ...

In Nature, Taniguchi and colleagues show that IFN-γ strongly suppresses osteoclastogenesis by interfering with the RANK-RANKL signaling pathway. IFN-γ induces rapid degradation of the RANK ...

Further, bone morphogenetic protein (BMP) and transforming growth factor (TGF)-b signaling pathways have been implicated in the regulation of RANKL-mediated osteoclast differentiation. In the ...