1 described a new abnormal hemoglobin in a Negro family in North Carolina. This hemoglobin, designated "I", migrated more rapidly than normal hemoglobin on filter-paper electrophoresis at pH 8.6 ...

By birth, γ-globin production is normally switched off, but a significant fraction of RBCs still contain a mixture of fetal and adult hemoglobin. Because the sickle-cell mutation is present only ...