Why is knowing the atomic structure of molecules useful? Learn why, and how information like this about protein structure is shared through a publicly available database.

By birth, γ-globin production is normally switched off, but a significant fraction of RBCs still contain a mixture of fetal and adult hemoglobin. Because the sickle-cell mutation is present only ...

There are many types of sickle cell disease. The majority of cases are divided into three subtypes depending on which genes you inherited: Hemoglobin is an iron-containing protein found in your ...

Sep. 12, 2024 — Researchers have found that being a carrier for sickle cell disease, known as having sickle cell trait, increases the risk of blood clots, a risk that is the same among diverse ...

A gene known as HbS was the center of a medical and evolutionary detective story that began in the middle 1940s in Africa. Doctors noticed that patients who had sickle cell anemia, a serious ...

The new gene therapies for sickle cell disease—including the gene-editing ... Not all inherited variants of haemoglobin are detrimental, a concept known as genetic polymorphism.

2024. Introducing a hemoglobin G-Makassar variant in HSCs by in vivo base editing treats sickle cell disease in mice. Mol Ther. (32)12:4353-4371. Kelsey Woodruff is a PhD candidate in the Termini Lab ...

There are more than 200 hemoglobin variants, yet only a few are clinically significant. Sickle cell anemia is a good example of a qualitative change, and the thalassemias are an example of ...

Sickle cell hemoglobin (HbS) behaves like normal hemoglobin when fully oxygenated, but at low oxygen tension the hydrophobic valine residues cause the HbS to polymerize, resulting in gel formation ...

The new gene therapies for sickle cell disease—including the gene-editing ... that raises fetal hemoglobin levels. The FDA approved it in 1998. But Orkin says hydroxyurea and other available ...