However, doctors differ in their views on testing ... HER2 positive on FISH, the amplified area was actually adjacent to HER2 and not within it 4. It may end up that higher resolution methods ...

In Europe, it is called the Ventana HER2 (4B5) test – already used for deciding HER2 status – and incorporates a scoring algorithm that helps pathologists to identify low expressors.

Conversely, a HER2-negative status reflects cells with typical amounts of HER2 proteins. "Until recently, the results of HER2 testing were ... IHC uses a scoring system of 0 to 3 to designate ...

Breast cancer classed as HER2-positive - defined as an immunohistochemical (IHC) score of three or more – accounts for somewhere between 20% to 25% of all patients with the disease. However ...