HIF1α is a subunit of HIF, or hypoxia-inducible factor ... impaired HIF1α function in T cells is a major T cell-intrinsic mechanism of therapeutic resistance to ICBs, like anti-CTLA-4 and ...

Because bioinformatic analysis confirmed that miR-206 carries the 5′-GGAAUG-3′ ‘seed’ region, which is the putative binding site of the 3′-UTR region of HIF-1α, and the aforementioned ...

Casdatifan targets a transcription factor that binds with other proteins to switch off the body’s anti-inflammatory ...