1), showing for the first time that a lincRNA promotes metastatic chromatin remodeling. Figure 1: Schematic presentation of HOTAIR function in breast cancer progression. Individual histone ...

These useful findings assigned a novel functional implication of histone acylation, crotonylation. Although the mechanistic insights have been provided in great detail regarding the role of the YEATS2 ...

Evaluation of: Lujambio A, Calin GA, Villanueva A et al.: A microRNA DNA methylation signature for human cancer metastasis. Proc. Natl Acad. Sci. USA 105(36),13556-13561 (2008). Metastasis is a ...

In different stages of metastasis, ROS can modulate tumor behavior by reprogramming DNA methylation, histone modification, noncoding RNA (ncRNA), and N6-methyladenosine (m6A) modification.

In the context of metastatic cancer, cell differentiation and neural diseases, we focus on epigenetic writers (PMTs), readers (Rme/Kme effectors) and erasers (demethylases) with functional relevance ...