such as a selective loss of neurons within the central nervous system and a slow progression of neurological deficits. Therefore, the pathophysiology of Huntington's disease is likely to be ...

引言在人类基因组的浩瀚密码中,一段名为"Huntingtin(HTT)"的基因序列暗藏杀机。当这个基因上出现过多CAG三核苷酸重复时,就会引发被称为"亨廷顿舞蹈症(Huntington's disease,HD)"的神经退行性疾病。患者从肢体不受控制地舞动开始,逐渐丧失运动能力、认知功能,最终走向生命的终点。2月11日Cell的研究报道“Distinct ...

Researchers from the Huntington's Disease Center, UCL Queen Square Institute of Neurology, and UK DRI at UCL have taken major steps forward in advancing MSH3-targeting therapies for Huntington's ...

11, 2025 — A new study has discovered in mouse models that genes associated with repairing mismatched DNA are critical in eliciting damages to neurons ... in Huntington's disease and ...

Huntington's disease kills a population of cells called striatal projection neurons, which are located in the striatum, a structure deep in the brain responsible for movement, many cognitive ...

Huntington's disease is one of the most common inherited neurodegenerative disorders that typically begins in adulthood and worsens over time. Patients begin to lose neurons in specific regions of ...

The stem cells were developed into neurons from the striatum, the brain region primarily impacted by Huntington's disease, making the model relevant to disease conditions. These neurons were then ...

HDBuzz reported live updates on Bluesky from the 2025 HD Therapeutics Conference. Read on for coverage of Day 2. #CHDI2025 ...

bit.bio’s new ioGlutamatergic Neurons HTT50CAG/WT provide a human, cell-based, in vitro model of Huntington’s Disease (HD) that accurately reflects the disease genotype. Offering industry-leading ...

In human neurons grown in the lab ... Tabrizi is the director of the Huntington’s Disease Centre at University College London. The researchers studied different doses in order to help future ...