在衰老研究的领域中,胰岛素样生长因子(IGF)和胰岛素样生长因子结合蛋白(IGFBP)的作用至关重要。尤其是 IGF-1,在细胞生长、代谢以及细胞凋亡(apoptosis)的调控方面发挥着关键作用;而 IGFBP,以 IGFBP-3 为代表,通过与 IGF 结合,影响它们与受体的相互作用 ...
Insulin-like growth factor binding protein-1 (IGFBP-1) is an inhibitor of insulin-like growth factor-I (IGF-I). IGF-I is highly expressed in pancreatic cancer cell lines; however, previous studies ...