The transcription factor XBP1, which is activated by the ER transmembrane protein IRE1 (inositol-requiring transmembrane kinase/endonuclease 1), is an important component of the UPR. XBP1 induces ...

Limited sensitivity to chemotherapy and an immunosuppressive tumor microenvironment drives breast cancer mortality in HER2 negative breast cancer. We have identified the IRE1/XBP1 branch of the ...