Ishii and colleagues now reveal that TBK1 (TANK-binding kinase 1) mediates the adjuvant effect of DNA vaccines and that this effect occurs independently of the TLR (Toll-like receptor) signalling ...

The transcription factor interferon regulatory factor 5 (IRF5) has previously been implicated in systemic lupus erythematosus (SLE) development, but its precise role in this process is unknown.

By inhibiting the function of TBK1, a gene previously associated with immune evasion, we were able to restore CAR-T cell activity, prevent dysfunction and increase T cell proliferation.