研究结果揭示了脾脏在心肌再灌注损伤中的远程调节作用，特别是IRF7作为关键靶点的 ... 中两种关键炎症因子IL-6和IFN-b的蛋白水平显著下降。

IRF7 and IRF3, known virus-inducible gene activators, were predicted to be activated in immunomodulatory imMKCLs. A total of 20 upstream regulators were predicted to be active in both cell ...

Here, the authors target the spleen to reduce acute heart injury and improve long-term cardiac function via transient IRF7 inhibition ... are needed for proper MZ B cell positioning/retention ...