A key function of IRS proteins in peripheral tissues is to couple insulin receptor activation to signaling via the PI3K signal transduction pathway, and in neurons, PI3K is implicated as a key ...

Investigators at the Helmholtz Institute have shown that inceptor, an inhibitor of the insulin signaling pathway, acted by binding insulin and targeting it for degradation. “Insulin was discovered 100 ...

Leptin and Insulin Resistance Pathway Convergence At the cellular level, leptin signaling intersects with insulin pathways in pancreatic β-cells. When leptin binds to its receptors in these cells ...

In 2021, a research team led by Prof. Heiko Lickert from Helmholtz Munich discovered the insulin-inhibitory receptor "Inceptor" and its role as a suppressor of the insulin signaling pathway.

In addition, there is evidence that in type 2 diabetes, the activation of these same pathways by elevations in glucose and free fatty acid (FFA) levels leads to both insulin resistance and ...

Three years ago, the inceptor protein was discovered and its role as an inhibitor of the insulin signaling pathway was described. Inceptor and the insulin receptor are located on the surface of ...

suggesting that insulin resistance occurred despite normal insulin signaling pathways. HFD-fed wild-type mice had elevated ...

Greeny, A, Nair, A, Sadanandan, P, Satarker, S, Famurewa, AC and Nampoothiri, M (2024) Epigenetic Alterations in Alzheimer's ...

Dopamine receptors bind dopamine, insulin receptors bind insulin ... through a sequence of molecular switches to internal signaling pathways. Membrane receptors fall into three major classes ...

This can disrupt insulin signaling pathways, a sign of insulin resistance. • Poor diet: Consuming a poor-quality diet high in processed foods, refined carbohydrates, and sugary beverages ...