生物的一生伴随着各种各样的压力，应激性是生物的本质特征之一。大脑是脊椎动物感知和调控压力的中枢，目前对神经元如何在细胞层面初始地感知并转导压力信号仍然缺乏清晰的认知。对此的研究有助于理解神经元在压力响应中的细胞学机制，并为焦虑症、抑郁症等神经精神疾病 ...

Fruit flies with genetic mutations that severely reduce sleep show enhanced performance in olfactory memory tasks, ...

The approval of two kinase-targeting drugs, Genentech's trastuzumab (Herceptin®) in 1998 and Novartis's imatinib (Gleevec®) in 2001, and their success as cancer therapeutics, validate the trend ...

Protein kinase research presents an opportunity to explore molecular targets in the body to treat diseases like cancer and ...

Your body produces the enzyme creatine kinase (CK) or creatine phosphokinase to keep your muscles functioning properly. Healthcare providers use the CK test to check levels of this protein in your ...

With over 15 years of experience in kinase drug discovery, DiscoverX offers the largest collection of nearly 500 biochemical and cell-based kinase assays. KINOMEscan® technology, our novel kinase ...

This new cryo-EM structure represents a remarkable advance in our understanding of how human PINK1 is stabilized” said ...

In 1987 I attended a meeting at Cold Spring Harbor on phosphatidylinositol signaling that turned out to be pivotal for me. A few years earlier I'd helped show that a phosphatidylinositol (PI) kinase ...