Her life-giving mythology is the reason she lends her name to a peculiarity of biology; the α-klotho protein. An increase or decrease in the abundance of this protein seems to lengthen or shorten ...

These ligands circulate throughout the body owing to weak affinity for HSGAG (heparan sulphate glycosaminoglycan), and they require α-klotho–β-klotho proteins as cofactors for their activity.

Klotho Neurosciences, Inc., a biopharmaceutical company, develops medicines for the treatment of cancer, cardiovascular, and neurodegenerative disorders. Its lead gene therapy product candidates ...