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炎症细胞因子在转移性休眠诱导与唤醒中的关键作用:乳腺癌研究新 ...
癌细胞感知 IFNγ可诱导转移性休眠 :为确定 IFN γ 是直接作用于癌细胞还是通过其他细胞间接发挥作用,研究人员构建了 IFN γ R1 缺陷的 4T07-LZ 细胞。实验显示,与对照肿瘤相比,IFN γ R1 缺陷的肿瘤从第 14 天开始大多出现体积减小,且肺部含有更多的 DCCs。这表明癌细胞对 IFN γ 的感知有助于转移性休眠的维持,IFN γ 是 CD8 + T ...
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