In parallel, a mouse model of colorectal adenocarcinoma (MC38) was utilized to assess the functional impact of microbiota-derived LPS on anti-PD-1 therapy. Mice were pre-treated with polymyxin B ...

LPS infusion in normal diet-fed mice causes a metabolic response similar, to some extent, to high-fat feeding. LPS receptor-deleted mice (i.e., CD14 mutants) are hypersensitive to insulin ...